AC Immune reports positive phase 2 trial results for ACI-7104
LAUSANNE, Switzerland - AC Immune SA revealed promising phase 2 trial results for ACI-7104, an active immunotherapy targeting alpha-synuclein protein aggregates, which contribute to neuron degeneration in Parkinson's disease. In Part 1 of the VacSYn trial, 34 patients received ACI-7104 or a placebo, with all patients generating antibodies against the target antigen following three immunizations.
The treatment was deemed safe and well-tolerated. Antibody penetration into cerebrospinal fluid was observed in all participants, and a signal was noted for total alpha-synuclein reactivity in the fluid, indicating potential target engagement. While Part 1 did not evaluate biomarker or clinical outcomes, exploratory analyses suggested a potential link between antibody levels and disease activity measures.
The trial will extend for two years before advancing to Part 2, designed to provide clinical activity evidence for a phase 3 decision. AC Immune, a clinical-stage biopharmaceutical company, has partnerships valued at over $4.5 billion in potential milestone payments and royalties.
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