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Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study

Nature Medicine, Published online: 22 September 2026; doi:10.1038/s41591-026-04618-w The interventional PATHFINDER 2 study provides insights on the safety and performance of a blood-based multi-cancer early detection test in an intended-use population, including more than 35,000 participants aged 50 years or older.

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