Molecular Architecture of the Human GCN1-ABCF3 Ribosome Collision Sensor
The Integrated Stress Response is a critical eukaryotic signaling pathway that maintains cellular proteostasis. During amino acid scarcity, the yeast kinase Gcn2 (GCN2 in humans) and its activators Gcn1/Gcn20 phosphorylate eIF2 to reprogram translation, but how GCN2 senses nutrient stress in mammals is not known. Ribosome collisions serve as a major physiological trigger. Here we report a cryo-EM…
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