MCT1 activity defines an aggressive metabolic phenotype and therapeutic target in non-small cell lung cancer
Lactate uptake through monocarboxylate transporter 1 (MCT1) is associated with aggressive disease in non-small cell lung cancer (NSCLC), but how lactate transport supports tumor metabolism remains incompletely understood. Integrating stable isotope tracing, metabolomics, and transcriptomics across patient tumors, animal models, and cultured cells, we show that elevated lactate utilization and…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
