Evaluations of retrospective frequency and phase correction methods for single-voxel MR spectroscopy at 7T
Subject motion and gradient heating-induced frequency and phase offsets result in spectral misalignment during single-voxel MR spectroscopy (SVS) acquisitions. Several methods have been presented to align the spectra, but their performance on a 7T system is unclear. This study aimed to evaluate the practical importance of four retrospective correction methods, namely creatine fitting, residual…
Single-voxel MR spectroscopy (SVS) acquisitions are affected by subject motion and gradient heating, leading to spectral misalignment. Researchers evaluated four retrospective correction methods for SVS data at a 7T system, namely creatine fitting, residual water, spectral registration, and cross-correlation. The study included 127 participants (88 female and 39 male, with an average age of 39±15 years) using a semi-localization by adiabatic selective refocusing sequence.
After correction, changes in spectral linewidth, signal-to-noise ratio (SNR), similarity (mean similarity matrix (SImean)), and metabolite quantification (concentration and relative Cramer-Rao lower bounds (rCRLB)) were assessed. A Wilcoxon signed rank test was used to compare these changes, with p-values adjusted using the false discovery rate (q 0.60).
The results showed that the correction had a weak to moderate effect on metabolite quantification, with an effect size not specified in the source material.
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