Engineering Persistent and Rewritable Genetic Memory in Bacteria through Multiscale Plasmid Competition
Genetic memory enables bacteria to record transient stimuli as persistent genetic states, providing a foundation for cellular information storage, sensing, and computation. Recombinase-based memories encode discrete states through rewritable DNA rearrangements, but these states can continue to evolve after stimulus removal as cells proliferate. Here, we show that the long-term stability of…
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