An N-Terminally Acetylated Degron Specifically Recognized by the CTLHMKLN1-FAM72A E3 Ubiquitin Ligase for Regulatory Protein Degradation
N-terminal acetylation of cellular proteins has been implicated in their proteasomal degradation through the Ac/N-degron pathway. Despite representing a major branch of the N-degron system, only a limited number of degrons and their motifs have been identified and characterized in this pathway, and the mechanism underpinning the recognition of N-terminal acetylation has remained largely elusive.…
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