A Dynamically Regulated Designed IL-2 for Tumor-localized Signaling
Cytokines mediate cell-cell communication to coordinate immune responses and hold clinical promise as immunotherapies. While natural cytokines are exquisitely regulated by immune cells, engineered cytokines have not yet matched this sophisticated regulation, limiting clinical efficacy and safety. IL-2 is an important cytokine involved in antitumor response, but its production is disrupted in the…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
