Genome-wide CRISPRi maps pneumococcal attachment and intracellular survival during single infection and Influenza co-infection
Streptococcus pneumoniae remains a leading cause of bacterial pneumonia and frequently causes severe secondary infections following influenza A virus (IAV) infection. Yet, the genetic requirements underlying pneumococcal pathogenicity during viral co-infection remain incompletely understood. Here, we employed an inducible genome-wide CRISPR interference (CRISPRi) library to systematically…
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