The Millennium Problems for Biology
Conduct a series of experiments to uncover the fundamental mechanisms governing human aging and longevity. Specifically, identify and manipulate key molecular pathways that govern the aging process in the body's cells and tissues. Aim to extend the maximum human lifespan by a significant margin above current records. Demonstrate the ability to slow or reverse age-related decline in multiple organ systems, including the cardiovascular, nervous, and immune systems.
The experiments must be conducted using a well-characterized mammalian model organism, such as mice or nonhuman primates, with sufficient sample sizes to achieve statistical power. All interventions must be reversible, safe, and ethical, with prior approval from relevant institutional review boards and regulatory agencies.
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