RfaH licenses RNA polymerase for long-range transcription
Processivity is essential for gene expression: Escherichia coli RNA polymerase (RNAP) must transcribe 10+ kbp operons without failure, yet backtrack-induced long-lived pauses threaten premature termination. Gre factors stimulate transcript cleavage to rescue backtracked RNAP, whereas NusA and NusG, which bridge the expressome, respectively stimulate and suppress pausing. How they cooperate to…
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