Split suppression gene drives reveal a design tradeoff between inheritance and reproductive load in Aedes aegypti
Mosquito-borne pathogens cause approximately 700,000 deaths annually, highlighting the need for effective and sustainable vector control strategies. CRISPR-based gene drives offer a potential approach for suppressing disease-vector populations, but autonomous drives may spread beyond intended populations. Split gene drives, in which the Cas9 and guide RNA components are genetically separated,…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
