Neuronal lipid composition regulates distinct states of full-length tau assembly, mechanics and membrane interactions
Aggregation of tau into fibrillar assemblies and neurofibrillary tangles is a defining feature of tauopathies. However, the role of the membrane-rich neuronal environment on the assembly and mechanics of full-length tau remains unclear. Here, we examined how neuronal lipid membranes affect the assembly and membrane interaction of full-length human tau (hTau40). Lipid composition redirected hTau40…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
