Closed-loop steering locates an evolutionary barrier to multidrug resistance in Escherichia coli
Resistance to one drug often raises susceptibility to another; such collateral sensitivity is expected to constrain multidrug resistance. This is hard to test: failure to reach a state is indistinguishable from never having been driven toward it. We therefore recorded the change we imposed: a closed-loop system updated each lineage's drug environment daily based on its measured distance to a…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
