Charged residues, not aromatics, are the universal topological hubs of intrinsically disordered proteins
The stickers and spacers model assigns aromatic residues as the primary drivers of IDP phase separation predicting that aromatics also occupy topologically central hub positions in IDP contact networks. Analysing a proteome wide simulation dataset spanning six taxa we find that charged residues not aromatics are the universal network hubs with glutamate the strongest hub in every taxon and…
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