Characterization of a fungal mixed-linkage glucan synthase
Mixed-linkage (1,3;1,4)-{beta}-glucan (MLG) is a cell wall polysaccharide found in fungi, bacteria, and plants, yet the enzymatic machinery and structural determinants governing fungal MLG biosynthesis remain poorly understood. In Aspergillus fumigatus, TFT1 (AfTFT1) has previously been implicated in MLG biosynthesis, but its direct biochemical activity remained unresolved. The structural…
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