Cell cycle exit is required for differentiation and cell fate diversification but not neoblast specialisation in planarians
In planarians, adult stem cells constantly proliferate and differentiate into dozens of different cell types to maintain tissue homeostasis. However, how cell fate acquisition is coordinated with cell cycle progression remains poorly understood. To address this, we generated single-cell RNA-sequencing datasets from cells enriched for 2C or 4C DNA content and from animals subjected to RNAi against…
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