Biochemical and Mechanistic Characterization of the DNA-dependent Poly(ADP-ribose) Polymerase, MoPARP1, in Magnaporthe oryzae
Poly(ADP-ribose) polymerases (PARPs) are important regulators of DNA repair and cellular stress responses in eukaryotes. Although mammalian PARPs have been extensively characterized, comparatively little is known about PARPs in pathogenic filamentous fungi. Here, we define biochemical features of MoPARP1 from the plant-pathogenic fungus Magnaporthe oryzae. Mutation of the conserved catalytic…
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