An atlas of transcription factor cooperation reveals how motif readers shape regulatory output
Regulatory motifs are conventionally associated with named transcription factors (TFs), yet a motif label need not identify the protein that reads the sequence or the regulatory consequence that follows in a given cell. We analyzed 1,552 TF binding datasets in 10 cell types using ARES, a multi-agent system that tests competing mechanisms of TF-motif dependencies in a specific cellular context…
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