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Age-related dynamics of DNA co-methylation modules in humans

Age-related changes in the mean or variance of DNA methylation (DNAm) at individual CpG sites are well established. However, CpGs that share biological functions often exhibit coordinated regulation. Here, we analysed whole-blood DNAm data from over 7,500 individuals and identified modules of co-methylated CpGs that either maintain consistent correlations with age (age-stable modules) or undergo…

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