A short C-terminal plug motif in a conserved type 4 pilus component controls pilus-tip localisation and filament biogenesis
Type 4a pili (T4aP), the most widespread and functionally versatile subtype of the type 4 filaments (T4F) superfamily, are functionalised at their tip by the adhesin PilC/PilY1. How this unusually large non-pilin protein is stably displayed at the pilus tip, and why is it required for pilus biogenesis, remains unknown. Here, using a multidisciplinary approach in Neisseria meningitidis, we show…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
