Replication Fork-Associated Checkpoint Mediator Mrc1/Claspin Acts in Arrest-Independent Double-Strand Break Survival
In budding yeast, the DNA damage checkpoint kinase Mec1ATR is the primary sensor of DSB-associated single-stranded DNA and coordinates cell cycle arrest with DNA repair. Deletion of Mec1 completely abolishes G2/M cell cycle arrest; however, approximately half of mec1{Delta} cells still survive an endonuclease-induced DSB, repairing the DSB either by single-strand annealing or break-induced…
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