Programmable DNA Assemblies Reconstitute Supramolecular Protein Function
Biological processes are often regulated through reactions involving supramolecular protein complexes organized with nanoscale precision, such as the apoptosome that activates procaspase-9 through defined stoichiometry to induce apoptosis. Here we report designer CASCAD (CARD Assembly on SCAffold DNA), a self-assembled DNA nanoplatform that spatially organizes caspase recruitment domains (CARDs),…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
