Parameters for stable Notch-independent Her6 oscillations across a frequency spectrum in neural stem cell populations
Neural proliferation zones drive the major growth phases of the vertebrate brain. Notch signaling and HES/Her transcription factors control neural stem cell (NSC) maintenance and neurogenesis, however the dynamic regulation of neural proliferation zones to sustain growth is not well understood. Notch-independent expression of the zebrafish HES1 homolog her6 in the larval brain is required for NSC…
Neural stem cell populations maintain growth through stable oscillations of Notch-independent Her6 expression. In zebrafish larvae, her6 - the HES1 homolog - ensures neurogenesis and NSC maintenance. By creating an mNeonGreen knock-in of her6, researchers observed Her6-mNeonGreen oscillations in vivo, unaffected by Notch signaling inhibition.
These oscillations span a wide frequency range, resuming after experimental disruptions. Mathematical modeling suggests that Her6's ability to maintain stemness during proliferation phases depends on equal transcript and protein degradation rate constants. This intrinsic control may have evolved to balance stemness, lineage stability, and plasticity.
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