Mitochondrial dysfunction and impaired osteogenic capacity define stress-induced osteoblast senescence
Cellular senescence has emerged as a key contributor to age-related skeletal deterioration; however, the defining characteristics of senescent osteoblasts remain incompletely understood, hindering efforts to identify the cellular mechanisms that drive age-associated bone loss and potential therapeutic targets. Here, we compared doxorubicin- and hydrogen peroxide-induced senescence and established…
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