Intrinsically disordered regions navigate DNA replication licensing factors to specific genomic loci.
Sites of DNA replication initiation are determined by binding of the Origin Recognition Complex (ORC, composed of Orc1-6) to specific genomic loci. Here, we determine the mechanism underlying site-specific binding of human Orc1. We find that Orc1's Bromo-Adjacent Homology (BAH) domain functions as an avidity element, whereas an intrinsically disordered region (IDR) guides genomic specificity.…
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