inteRelate: flexible and thorough relating of genomic interval datasets through comparative overlap analysis
Summary Testing spatial relationships between genome-mapped features is both a common source of hypothesis generation and an additional layer of supporting evidence for experimental findings. Many computational tools automate the statistical association procedures used to assess overlap between pairs of genomic features. However, none provides a dedicated workflow that directly compares multiple…
InteRelate is a software package designed for comparing multiple genome-mapped features through comparative overlap analysis. This tool automates statistical association procedures to assess the spatial relationships between genome-mapped features, generating hypotheses and providing supporting evidence for experimental findings.
While many computational tools exist for pairwise comparisons of genomic features, none offer a dedicated workflow for comparing multiple features by first testing for overall heterogeneity and then identifying which overlap rates differ.
InteRelate functions as an end-to-end pipeline, providing a thorough and tunable approach to testing spatial relationships between genome-mapped features. The package utilizes genomic interval datasets to automate the comparison process, ensuring accuracy and insight. To demonstrate its effectiveness, inteRelate was applied to experimental data, showcasing its ability to automate the analysis, validate results, and provide meaningful insights.
InteRelate is freely available for download at https://github.com/loggy01/interelate, with archived versions also accessible at https://zenodo.org/records/21891072. The developers have provided example uses for inteRelate in the online supplement, and the example datasets and results are available at https://zenodo.org/records/22012767.
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