How To Watch Lions vs. Bills And All Of The Week 2 NFL Primetime Games

The NFL commences Week 2 with an engaging primetime lineup. Thursday night's matchup of interest is between the Detroit Lions and the Buffalo Bills at 8:15 p.m. ET on Amazon Prime Video. This game marked the debut for both teams in the regular season, taking place at the newly opened Highmark Stadium by Buffalo. The teams enter with impressive wins - the Lions defeating the Saints 31-30 in overtime and the Bills overpowering the Texans 36-31.

Expect a high number of scoring plays in this game due to the limited resistance both defenses faced in their previous games.

The following day, the Indianapolis Colts face off against the Kansas City Chiefs at 8:20 p.m. ET on NBC/Peacock. The Chiefs, home in primetime for the second week in a row, follow a dominant win over the Broncos with a favored status by nearly a touchdown. They will be playing against the struggling Colts, whose performance against the Ravens in the previous week was less than stellar.

Daniel Jones for Indianapolis, making his return from injury, hasn't shown much mobility in Week 1. However, a win for the Chiefs could provide an early lead in the AFC West, especially if the Broncos and/or Chargers falter. The Colts aim to prevent falling too far behind in the divisional race, where the Texans and Jaguars pose competition.

On Monday, the New York Giants and Los Angeles Rams go head-to-head at 8:15 p.m. ET on ESPN/ABC/ESPN Unlimited. The Giants start the season 1-0, courtesy of their coach John Harbaugh, who rates beating the Cowboys as his top priority. The Rams, with a loss in Week 1 to the 49ers in Australia, are at a disadvantage. A win against the Giants for the Rams could help them avoid a 0-4 start and an early season trip to the tough matches against the Eagles and Broncos.

The absence of key offseason addition Myles Garrett, expected to return in October, could also impact their performance. Conversely, a strong showing by the Giants might position them as potential NFC favorites due to their relatively easier schedule.