H3-K27M mutation alters the dynamics of human hematopoietic stem cells and delays erythroid differentiation
Acute myeloid leukemia (AML) is an aggressive blood cancer driven by genetic and epigenetic alterations that disrupt normal hematopoiesis. Among these, the histone H3-K27M mutation, originally identified in pediatric high-grade gliomas, reshapes gene repression programs by reducing global H3-K27 trimethylation. Although rare, H3-K27M mutations have been detected in preleukemic hematopoietic stem…
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