Gene editing using large insertions
Nature Biotechnology, Published online: 17 September 2026; doi:10.1038/s41587-026-03319-6 While technologies for smaller gene edits, such as base editing, have already entered clinical trials, larger gene cargoes face different challenges, including low editing efficiencies, delivery vehicle size constraints, and possible immunogenicity. Programmable genome engineering systems using recombinases;…
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