From Nagelkerke's R2 to Liability-Scale Variance Explained for Polygenic Scores
It is desirable to quantify the prediction accuracy of polygenic scores (PGS) for disease on the scale of liability and adjusted for case-control ascertainment in the test sample, because that allows comparison across prevalence and ascertainment. Previous expressions have focused in their derivation and implementation on linear regression on the observed 0-1 scale followed by a transformation of…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
