Evidence for early kidney vasculature development by vasculogenesis and angiogenesis based on advanced in vivo chimeric model and depletion of CD31+/CD146+ intrinsic endothelial progenitors
Kidney diseases are a significant health concern worldwide, with a growing demand for fundamental treatments, such as generation of transplantable organs from programmed cells. The generation of kidney organoids has led to significant advances in disease modeling. However, failure to establish a robust endothelial vasculature network in kidney organoids remains a barrier to oxygen support and gas…
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