EphA3 couples attractive guidance to persistent retinal axon growth through modulation of EphA4 forward signaling in a plasma membrane cholesterol-dependent manner
Topographic mapping requires retinal axons not only to avoid inappropriate targets but also to advance directionally through permissive and attractive territories. Using chick retinal ganglion cells in stripe and Dunn chamber gradient assays, we investigated how extracellular EphA3 coordinates the directional guidance and growth dynamics of nasal axons. Nasal axons preferentially grew on…
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