Dynamic expression range expansion of ECF sigma factor-dependent synthetic regulons by promoter context engineering
Alternative {sigma} factors enable bacteria to reprogram transcription in response to environmental cues and provide powerful tools for synthetic gene regulation. Extracytoplasmic function (ECF) {sigma} factors have recently been implemented as orthogonal transcriptional switches in several bacteria, including the -proteobacterium Sinorhizobium meliloti. Here, we investigated how promoter…
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