Distinct regulation of collagen biosynthesis by hypoxia and vitamin C uncovers an essential role for CXCL12-CXCR4 signaling
Collagen biosynthesis is a complex multistep process, essential for functional tissue formation and repair. It is highly active during embryogenesis and wound healing, leading to physiological fibrogenesis, while its dysregulation induces pathologies affecting connective tissues, namely fibrosis. There are several key cellular microenvironmental factors regulating collagen biosynthesis, including…
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