Calcium signals at cytoneme contacts amplify Wnt/β-catenin signalling
Wnt signalling controls morphogenesis, patterning and homeostasis across tissues. Because Wnt ligands are lipid-modified, their movement between cells cannot rely on simple diffusion and instead requires specialised transport mechanisms. Signalling filopodia, also known as cytonemes, have emerged as a key mediator of contact-dependent morphogen delivery. The mechanisms that stabilise signalling…
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