A Tumor-Pituitary-Stromal Axis Promotes Colorectal Cancer Progression
Peripheral tumors can reprogram systemic physiology, yet how they engage central endocrine organs to remodel the local tumor microenvironment is unknown. We found that colorectal cancer (CRC) elevates circulating BMP2, which activates pituitary signaling and enhances endocrine output. Increased pituitary-derived growth hormone acted on growth hormone receptor-expressing cancer-associated…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
