A Latent Inflammatory Tissue-State Variable Mechanistically Links Radiotherapy-Induced Immune Remodeling to Recurrent Tumor Permissiveness
Triple-negative breast cancer recurrence following radiotherapy is associated with a microenvironment characterized by immune dysfunction and persistent inflammation. We developed an experimentally constrained agent-based model to investigate how transient immune remodeling becomes a persistent recurrence-permissive tissue state. The model reproduced experimentally observed macrophage recruitment…
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