U.S. stocks lower at close of trade; Dow Jones Industrial Average down 1.21%

U.S. stocks closed lower on Wednesday, with the Dow Jones Industrial Average slipping 1.21% to an 11-week low. The S&P 500 index slipped 0.44% and the NASDAQ Composite fell 0.01%. Among the Dow Jones Industrial Average's components, Honeywell International Inc. led gains, climbing 2.07% to close at 207.66. However, leading losses were seen in IBM, Goldman Sachs Group, and American Express.

For the S&P 500, Axon Enterprise Inc., GE Vernova LLC, and Edwards Lifesciences Corp. were the top gainers, while JB Hunt Transport Services, ON Semiconductor, and Diamondback Energy were the worst performers. The NASDAQ Composite's best performers were Delixy Holdings Ltd, DataMeds AI Inc, and Synergy CHC Corp, with the worst being Xenetic Biosciences Inc, Cuprina Holdings Inc, and Myseum Inc. The CBOE Volatility Index rose 2.97% to 17.71.

Gold Futures dropped 0.80% to $4,298.34 per troy ounce, while crude oil and Brent oil fell 3.53% and 2.98% respectively. EUR/USD declined 0.68% to 1.15 and USD/JPY rose 0.82% to 156.38. The US Dollar Index Futures edged up 0.73% to 100.07.