Temporal transcriptomic remodeling after controlled cortical impact reveals delayed AQP4/SNTA1 expression imbalance associated with ion-homeostatic remodeling
Traumatic brain injury (TBI) is often viewed as a progressively evolving molecular response, yet the molecular and cellular responses that dictate acute TBI may differ fundamentally from those that define the chronically remodeled brain. We integrated temporally-resolved transcriptomic analyses with independent mouse, human, proteomic, and spatial datasets to determine how neural-circuit and…
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