Prophylactic Phage Therapy Protects Mice Against Oral Salmonella Infection
Researchers developed a prophylactic phage therapy targeting Salmonella enterica Typhimurium that in mouse models colonized the gut, and produced lytic phages that protected against future infection by the pathogen, improving survival. The post Prophylactic Phage Therapy Protects Mice Against Oral Salmonella Infection appeared first on GEN - Genetic Engineering and Biotechnology News .
Researchers at Virginia Tech have developed a new prophylactic phage therapy approach to protect against potential future infections by pathogenic gut bacteria. This method involves engineering a nonpathogenic Escherichia coli bacterium that produces a bacteriophage specifically targeting the Salmonella enterica Typhimurium (STm) pathogen.
The team, led by associate professor Bryan Hsu, PhD, demonstrated that this engineered bacterium, when administered before oral STm infection, colonized the gut, produced high levels of lytic phage, and significantly improved survival in mouse models compared to other treatment methods. The researchers believe this advancement could pave the way for new therapeutic options against various diseases, particularly those caused by enteric bacterial infections, such as Salmonella.
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