Penn State vs Buffalo Prediction: Another Nittany Lion Scrimmage

Penn State's Matt Campbell era kicked off with a big win over Marshall and Temple, combining for a score of 102-9, while Buffalo remains at 1-1. However, the Bulls faced a tough loss against FIU in the previous game. The MAC season will commence in early October, with Penn State taking on Western Michigan first.

Buffalo will enjoy a breather at Robert Morris before facing Penn State. This matchup marks the start of the Big Ten season for both teams. Penn State will kick off their Big Ten season against Wisconsin in the following week, marking their third home game within the first four weeks of the season.

Historically, Penn State leads the all-time series against Buffalo with a 3-0 record, including victories of 45-13 in 2019, 27-14 in 2015, and 45-24 in 2007.

Ahead of the game on Saturday, September 19, 2026, at 12:00 PM ET, the broadcast will be available on BTN, with the match taking place at Beaver Stadium in University Park, PA. As per CFN Expert Picks, the prediction for Week 3 is Penn State. The consensus line for the game is Penn State -40.5, with an over/under of 50.5. Becht has been impressive in his early games, hitting 76% of his passes, scoring seven touchdowns, and making no interceptions.

Buffalo's strong run defense and key players like Ronnell Davis, SaVeon Brown, and Stevie Bracey bolster their chances, while Penn State's quarterback Rocco Becht has shown promise in passing.