Genome-scale perturbation signatures from primary human CD4+ T cells improve genetics-based prioritization of immune drug targets
While human genetic evidence improves drug program success, target selection largely relies on associational features. Even functional features are mainly observational, capturing disease associations rather than the consequence of perturbing genes in the disease-relevant human cell type. To move beyond association, we present IGNITE (Immune Genomics and fuNctional Integration for Target…
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