Study Links Weight Loss Medicines to Depression and Suicidal Thoughts

A new study reveals a link between prescription weight-loss drugs and an increased likelihood of depression and suicidal thoughts among users. Researchers from Asan Medical Center in South Korea examined data from 27,741 adults surveyed between 2013 and 2022. Of these, 10,908 individuals had used weight-loss medication for at least a year, while 26,895 had not.

The study found that 22.1% of users experienced depressive feelings for two or more consecutive weeks, compared to 11.4% of non-users. Suicidal thoughts were reported by 9.9% of users versus 4.5% of non-users, with 2.2% of users contemplating suicide versus 1.4% of non-users. Suicide attempts were reported by 1.7% of users and 0.6% of non-users.

After adjusting for other factors, users had 93% higher odds of depression and 168% higher odds of suicidal thoughts than non-users. The association was most pronounced among those who gained weight after using the medication, with a 4.2 times higher risk of suicidal thoughts. Researchers believe the rise in mental health issues could stem from neuropsychiatric effects of the drugs or psychological stress from unsuccessful weight control or regaining weight.

While the study shows an association, it does not prove cause and effect. Health regulators have previously reviewed concerns over suicidal thoughts linked to weight-loss drugs.