Piercing mechanism in the minimal contractile tail of bacteriophage P2.
Bacteriophage P2 is a long-standing model for contractile injection systems, yet high-resolution structures of the intact virion and the mechanism of baseplate activation have remained unresolved. Here, we combine high-resolution cryo-electron microscopy and in situ cryo-electron tomography to characterize P2, using its lytic mutant P2vir, in its pre- and post-contraction states and during host…
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