Scientists discover dispersal mechanism and new gene family in harmful E. coli strains
Researchers from Tokyo Metropolitan University have identified how certain dangerous bacteria spread. They studied chain-like adherence pattern (CLAP) varieties of Shiga toxin-producing E. coli (STEC), finding that single bacteria attach to a surface and elongate before dividing, producing chains without ever separating.
Researchers from Tokyo Metropolitan University have identified a new dispersal mechanism and gene family in harmful E. coli strains. They focused on chain-like adherence pattern (CLAP) varieties of Shiga toxin-producing E. coli (STEC), which can form chains without separating. Under flow, torn off chain ends can attach elsewhere, spreading the strain.
The team discovered a new gene family, the Cla adhesin family, responsible for CLAP formation. This revelation sheds light on infection mechanisms and potential treatments for LEE-negative STEC strains, which can be as deadly as LEE-positive strains despite lacking the locus of enterocyte effacement.
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