Opening odds see Bills looking to make a statement vs. Lions in Week 2

The Buffalo Bills and Detroit Lions are set to clash in a Week 2 matchup for Thursday Night Football on Prime Video, with the Bills serving as 4.5-point favorites. FanDuel Sportsbook lists the Bills at -4.5 against the Lions, while the moneyline stands at -220 for Buffalo and +184 for Detroit. The over/under is set at 53.5 points (-105 Bills/-115 Lions).

This will be the first time Buffalo quarterback Josh Allen plays at home against Detroit, as the two teams have never won a Super Bowl and have not played in a post-merger championship. In their last meeting, the Bills emerged victorious with a 48-42 score, with Allen throwing for 362 yards and two touchdowns, and running back James Cook III contributing 105 rushing yards and two scores.

Quarterback Jared Goff of the Lions delivered a stellar game with 494 passing yards and five touchdowns, while wide receiver Amon-Ra St. Brown had a standout performance with 14 receptions for 193 yards and a touchdown.