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LIGER2: Scalable Single-Cell Integration with On-Disk Datasets

Correcting batch effects and integrating single-cell sequencing datasets has been a crucial step in large-scale biological studies. Many methods have been published for this task, and excel in various scenarios. Our previous work, LIGER, leveraging integrative non-negative matrix factorization (iNMF), stands out in providing an interpretable low-dimensional representation. To adapt to the modern…

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A clownfish’s last stand

Twenty years ago, scientist and Mongabay board member Debby Ng joined a team documenting life at Terumbu Bayan, a coral reef south of Singapore that was about to be reclaimed.

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