Rtel1 in hypothalamic oxytocin neurons regulates oxytocin output and social behaviors in mice
RTEL1, a DNA helicase that resolves G-quadruplexes to maintain telomere and genome stability, has emerged as a candidate autism spectrum disorder risk gene, but its neural functions remain unknown. Here, we show that Rtel1 haploinsufficiency in mice impairs social novelty and increases marble burying and anxiety-related behaviors without affecting locomotion or spatial learning. RTEL1 is…
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