M.FcoHsdM-dependent DNA methylation coordinates secretion-associated gene expression, interbacterial competition, and virulence in Flavobacterium columnare
Flavobacterium columnare causes columnaris disease in freshwater fish, but the contribution of DNA methylation to its physiology and pathogenicity remains poorly understood. Here, we characterized M. FcoHsdM, a type I restriction-modification methyltransferase previously identified by nanopore methylome analysis. Deletion of the gene encoding M. FcoHsdM abolished methylation at its associated…
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